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Research Article

IL-1β Signaling Promotes CNS-Intrinsic Immune Control of West Nile Virus Infection

  • Hilario J. Ramos,

    Affiliation: Department of Immunology, University of Washington School of Medicine, Seattle, Washington, United States of America

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  • Marion C. Lanteri,

    Affiliation: Blood Systems Research Institute, San Francisco, California, United States of America

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  • Gabriele Blahnik,

    Affiliation: Department of Immunology, University of Washington School of Medicine, Seattle, Washington, United States of America

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  • Amina Negash,

    Affiliation: Department of Immunology, University of Washington School of Medicine, Seattle, Washington, United States of America

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  • Mehul S. Suthar,

    Affiliation: Department of Immunology, University of Washington School of Medicine, Seattle, Washington, United States of America

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  • Margaret M. Brassil,

    Affiliation: Department of Immunology, University of Washington School of Medicine, Seattle, Washington, United States of America

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  • Khushbu Sodhi,

    Affiliation: Department of Immunology, University of Washington School of Medicine, Seattle, Washington, United States of America

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  • Piper M. Treuting,

    Affiliation: Department of Comparative Medicine, University of Washington School of Medicine, Seattle, Washington, United States of America

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  • Michael P. Busch,

    Affiliations: Blood Systems Research Institute, San Francisco, California, United States of America, Department of Laboratory Medicine, University of California San Francisco, San Francisco, California, United States of America, Department of Medicine, University of California San Francisco, San Francisco, California, United States of America

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  • Philip J. Norris,

    Affiliations: Blood Systems Research Institute, San Francisco, California, United States of America, Department of Laboratory Medicine, University of California San Francisco, San Francisco, California, United States of America, Department of Medicine, University of California San Francisco, San Francisco, California, United States of America

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  • Michael Gale Jr. mail

    mgale@u.washington.edu

    Affiliations: Department of Immunology, University of Washington School of Medicine, Seattle, Washington, United States of America, Department of Microbiology, University of Washington School of Medicine, Seattle, Washington, United States of America

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  • Published: November 29, 2012
  • DOI: 10.1371/journal.ppat.1003039

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