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Research Article

A Trade-off between the Fitness Cost of Functional Integrases and Long-term Stability of Integrons

  • Irina Starikova,

    Affiliation: Department of Pharmacy, Faculty of Health Sciences, University of Tromsø, Tromsø, Norway

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  • Klaus Harms,

    Affiliation: Department of Pharmacy, Faculty of Health Sciences, University of Tromsø, Tromsø, Norway

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  • Pål Haugen,

    Affiliation: Department of Pharmacy, Faculty of Health Sciences, University of Tromsø, Tromsø, Norway

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  • Tracy T. M. Lunde,

    Affiliation: Reference Centre for Detection of Antimicrobial Resistance, Department of Microbiology and Infection Control, University Hospital of North Norway, Tromsø, Norway

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  • Raul Primicerio,

    Affiliation: Department of Pharmacy, Faculty of Health Sciences, University of Tromsø, Tromsø, Norway

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  • Ørjan Samuelsen,

    Affiliation: Reference Centre for Detection of Antimicrobial Resistance, Department of Microbiology and Infection Control, University Hospital of North Norway, Tromsø, Norway

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  • Kaare M. Nielsen,

    Affiliations: Department of Pharmacy, Faculty of Health Sciences, University of Tromsø, Tromsø, Norway, GenØk, Center for Biosafety, Research Park, Tromsø, Norway

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  • Pål J. Johnsen mail

    paal.johnsen@uit.no

    Affiliation: Department of Pharmacy, Faculty of Health Sciences, University of Tromsø, Tromsø, Norway

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  • Published: November 29, 2012
  • DOI: 10.1371/journal.ppat.1003043

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