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Research Article

The Polyfunctionality of Human Memory CD8+ T Cells Elicited by Acute and Chronic Virus Infections Is Not Influenced by Age

  • Alina Lelic,

    Affiliation: McMaster Immunology Research Centre, Department of Pathology and Molecular Medicine, McMaster University, Hamilton, Ontario, Canada

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  • Chris P. Verschoor,

    Affiliation: McMaster Immunology Research Centre, Department of Pathology and Molecular Medicine, McMaster University, Hamilton, Ontario, Canada

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  • Mario Ventresca,

    Affiliation: Department of Mechanical and Industrial Engineering, University of Toronto, Toronto, Ontario, Canada

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  • Robin Parsons,

    Affiliation: McMaster Immunology Research Centre, Department of Pathology and Molecular Medicine, McMaster University, Hamilton, Ontario, Canada

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  • Carole Evelegh,

    Affiliation: McMaster Immunology Research Centre, Department of Pathology and Molecular Medicine, McMaster University, Hamilton, Ontario, Canada

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  • Dawn Bowdish,

    Affiliation: McMaster Immunology Research Centre, Department of Pathology and Molecular Medicine, McMaster University, Hamilton, Ontario, Canada

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  • Michael R. Betts,

    Affiliation: Department of Microbiology, University of Pennsylvania, Philadelphia, Pennsylvania, United States

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  • Mark B. Loeb,

    Affiliation: McMaster Immunology Research Centre, Department of Pathology and Molecular Medicine, McMaster University, Hamilton, Ontario, Canada

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  • Jonathan L. Bramson mail

    bramsonj@mcmaster.ca

    Affiliation: McMaster Immunology Research Centre, Department of Pathology and Molecular Medicine, McMaster University, Hamilton, Ontario, Canada

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  • Published: December 13, 2012
  • DOI: 10.1371/journal.ppat.1003076

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