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Research Article

Cooperativity Between CD8+ T Cells, Non-Neutralizing Antibodies, and Alveolar Macrophages Is Important for Heterosubtypic Influenza Virus Immunity

  • Brian J. Laidlaw,

    Affiliation: Department of Microbiology and Institute for Immunology, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania, United States of America

    Current address: Department of Immunobiology, Yale University, New Haven, Connecticut.

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  • Vilma Decman,

    Affiliation: The Wistar Institute, Philadelphia, Pennsylvania, United States of America

    Current address: Regeneron Pharmaceuticals, Tarrytown, New York.

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  • Mohammed-Alkhatim A. Ali,

    Affiliation: Department of Microbiology and Institute for Immunology, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania, United States of America

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  • Michael C. Abt,

    Affiliation: Department of Microbiology and Institute for Immunology, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania, United States of America

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  • Amaya I. Wolf,

    Affiliation: The Wistar Institute, Philadelphia, Pennsylvania, United States of America

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  • Laurel A. Monticelli,

    Affiliation: Department of Microbiology and Institute for Immunology, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania, United States of America

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  • Krystyna Mozdzanowska,

    Affiliation: The Wistar Institute, Philadelphia, Pennsylvania, United States of America

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  • Jill M. Angelosanto,

    Affiliation: Department of Microbiology and Institute for Immunology, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania, United States of America

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  • David Artis,

    Affiliation: Department of Microbiology and Institute for Immunology, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania, United States of America

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  • Jan Erikson,

    Affiliation: The Wistar Institute, Philadelphia, Pennsylvania, United States of America

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  • E. John Wherry mail

    wherry@mail.med.upenn.edu

    Affiliation: Department of Microbiology and Institute for Immunology, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania, United States of America

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  • Published: March 14, 2013
  • DOI: 10.1371/journal.ppat.1003207

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