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Research Article

Broadly Neutralizing Antibody PGT121 Allosterically Modulates CD4 Binding via Recognition of the HIV-1 gp120 V3 Base and Multiple Surrounding Glycans

  • Jean-Philippe Julien,

    Affiliations: Department of Integrative Structural and Computational Biology, The Scripps Research Institute, La Jolla, California, United States of America, IAVI Neutralizing Antibody Center, The Scripps Research Institute, La Jolla, California, United States of America, CHAVI-ID, The Scripps Research Institute, La Jolla, California, United States of America

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  • Devin Sok,

    Affiliations: IAVI Neutralizing Antibody Center, The Scripps Research Institute, La Jolla, California, United States of America, CHAVI-ID, The Scripps Research Institute, La Jolla, California, United States of America, Department of Immunology and Microbial Science, The Scripps Research Institute, La Jolla, California, United States of America

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  • Reza Khayat,

    Affiliations: Department of Integrative Structural and Computational Biology, The Scripps Research Institute, La Jolla, California, United States of America, IAVI Neutralizing Antibody Center, The Scripps Research Institute, La Jolla, California, United States of America, CHAVI-ID, The Scripps Research Institute, La Jolla, California, United States of America

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  • Jeong Hyun Lee,

    Affiliations: Department of Integrative Structural and Computational Biology, The Scripps Research Institute, La Jolla, California, United States of America, IAVI Neutralizing Antibody Center, The Scripps Research Institute, La Jolla, California, United States of America, CHAVI-ID, The Scripps Research Institute, La Jolla, California, United States of America

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  • Katie J. Doores,

    Affiliations: IAVI Neutralizing Antibody Center, The Scripps Research Institute, La Jolla, California, United States of America, CHAVI-ID, The Scripps Research Institute, La Jolla, California, United States of America, Department of Immunology and Microbial Science, The Scripps Research Institute, La Jolla, California, United States of America

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  • Laura M. Walker,

    Affiliations: IAVI Neutralizing Antibody Center, The Scripps Research Institute, La Jolla, California, United States of America, CHAVI-ID, The Scripps Research Institute, La Jolla, California, United States of America, Department of Immunology and Microbial Science, The Scripps Research Institute, La Jolla, California, United States of America

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  • Alejandra Ramos,

    Affiliation: IAVI Neutralizing Antibody Center, The Scripps Research Institute, La Jolla, California, United States of America

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  • Devan C. Diwanji,

    Affiliations: Department of Integrative Structural and Computational Biology, The Scripps Research Institute, La Jolla, California, United States of America, IAVI Neutralizing Antibody Center, The Scripps Research Institute, La Jolla, California, United States of America, CHAVI-ID, The Scripps Research Institute, La Jolla, California, United States of America

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  • Robert Pejchal,

    Affiliations: Department of Integrative Structural and Computational Biology, The Scripps Research Institute, La Jolla, California, United States of America, IAVI Neutralizing Antibody Center, The Scripps Research Institute, La Jolla, California, United States of America, CHAVI-ID, The Scripps Research Institute, La Jolla, California, United States of America

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  • Albert Cupo,

    Affiliation: Weill Medical College of Cornell University, New York, New York, United States of America

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  • Umesh Katpally,

    Affiliation: Weill Medical College of Cornell University, New York, New York, United States of America

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  • Rafael S. Depetris,

    Affiliation: Weill Medical College of Cornell University, New York, New York, United States of America

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  • Robyn L. Stanfield,

    Affiliations: Department of Integrative Structural and Computational Biology, The Scripps Research Institute, La Jolla, California, United States of America, IAVI Neutralizing Antibody Center, The Scripps Research Institute, La Jolla, California, United States of America, CHAVI-ID, The Scripps Research Institute, La Jolla, California, United States of America

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  • Ryan McBride,

    Affiliation: Department of Chemical Physiology, The Scripps Research Institute, La Jolla, California, United States of America

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  • Andre J. Marozsan,

    Affiliation: Weill Medical College of Cornell University, New York, New York, United States of America

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  • James C. Paulson,

    Affiliations: Department of Integrative Structural and Computational Biology, The Scripps Research Institute, La Jolla, California, United States of America, Department of Chemical Physiology, The Scripps Research Institute, La Jolla, California, United States of America

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  • Rogier W. Sanders,

    Affiliations: Weill Medical College of Cornell University, New York, New York, United States of America, Department of Medical Microbiology, Academic Medical Center, Amsterdam, Netherlands

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  • John P. Moore,

    Affiliation: Weill Medical College of Cornell University, New York, New York, United States of America

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  • Dennis R. Burton,

    Affiliations: IAVI Neutralizing Antibody Center, The Scripps Research Institute, La Jolla, California, United States of America, CHAVI-ID, The Scripps Research Institute, La Jolla, California, United States of America, Department of Immunology and Microbial Science, The Scripps Research Institute, La Jolla, California, United States of America, Ragon Institute of MGH, MIT, and Harvard, Cambridge, Massachusetts, United States of America

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  • Pascal Poignard,

    Affiliations: IAVI Neutralizing Antibody Center, The Scripps Research Institute, La Jolla, California, United States of America, Department of Immunology and Microbial Science, The Scripps Research Institute, La Jolla, California, United States of America

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  • Andrew B. Ward mail,

    abward@scripps.edu (ABW); wilson@scripps.edu (IAW)

    Affiliations: Department of Integrative Structural and Computational Biology, The Scripps Research Institute, La Jolla, California, United States of America, IAVI Neutralizing Antibody Center, The Scripps Research Institute, La Jolla, California, United States of America, CHAVI-ID, The Scripps Research Institute, La Jolla, California, United States of America

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  • Ian A. Wilson mail

    abward@scripps.edu (ABW); wilson@scripps.edu (IAW)

    Affiliations: Department of Integrative Structural and Computational Biology, The Scripps Research Institute, La Jolla, California, United States of America, IAVI Neutralizing Antibody Center, The Scripps Research Institute, La Jolla, California, United States of America, CHAVI-ID, The Scripps Research Institute, La Jolla, California, United States of America, Skaggs Institute for Chemical Biology, The Scripps Research Institute, La Jolla, California, United States of America

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  • Published: May 02, 2013
  • DOI: 10.1371/journal.ppat.1003342

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