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Research Article

Gain-of-Sensitivity Mutations in a Trim5-Resistant Primary Isolate of Pathogenic SIV Identify Two Independent Conserved Determinants of Trim5α Specificity

  • Kevin R. McCarthy,

    Affiliations: Harvard Program in Virology, Harvard Medical School, Boston, Massachusetts, United States of America, Biology Department, Boston College, Chestnut Hill, Massachusetts, United States of America

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  • Aaron G. Schmidt,

    Affiliation: Laboratory of Molecular Medicine, Children's Hospital, Harvard Medical School, Boston, Massachusetts, United States of America

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  • Andrea Kirmaier,

    Affiliation: Biology Department, Boston College, Chestnut Hill, Massachusetts, United States of America

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  • Allison L. Wyand,

    Affiliation: Biology Department, Boston College, Chestnut Hill, Massachusetts, United States of America

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  • Ruchi M. Newman,

    Affiliation: Broad Institute of MIT and Harvard, Cambridge, Massachusetts, United States of America

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  • Welkin E. Johnson mail

    welkin.johnson@bc.edu

    Affiliation: Biology Department, Boston College, Chestnut Hill, Massachusetts, United States of America

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  • Published: May 09, 2013
  • DOI: 10.1371/journal.ppat.1003352

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