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Research Article

Group B Streptococcal Infection of the Choriodecidua Induces Dysfunction of the Cytokeratin Network in Amniotic Epithelium: A Pathway to Membrane Weakening

  • Jeroen P. Vanderhoeven,

    Affiliation: Department of Obstetrics & Gynecology, University of Washington, Seattle, Washington, United States of America

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  • Craig J. Bierle,

    Affiliation: Center for Childhood Infections and Prematurity Research, Seattle Children's Research Institute, Seattle, Washington, United States of America

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  • Raj P. Kapur,

    Affiliation: Departments of Pathology, Seattle Children's and University of Washington, Seattle, Washington, United States of America

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  • Ryan M. McAdams,

    Affiliation: Department of Pediatrics, University of Washington, Seattle, Washington, United States of America

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  • Richard P. Beyer,

    Affiliation: Department of Environmental and Occupational Health Sciences, University of Washington, Seattle, Washington, United States of America

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  • Theo K. Bammler,

    Affiliation: Department of Environmental and Occupational Health Sciences, University of Washington, Seattle, Washington, United States of America

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  • Federico M. Farin,

    Affiliation: Department of Environmental and Occupational Health Sciences, University of Washington, Seattle, Washington, United States of America

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  • Aasthaa Bansal,

    Affiliation: Department of Biostatistics, University of Washington, Seattle, Washington, United States of America

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  • Min Spencer,

    Affiliation: Center on Human Development and Disability, University of Washington, Seattle, Washington, United States of America

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  • Mei Deng,

    Affiliation: Center on Human Development and Disability, University of Washington, Seattle, Washington, United States of America

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  • Michael G. Gravett,

    Affiliations: Department of Obstetrics & Gynecology, University of Washington, Seattle, Washington, United States of America, Global Alliance to Prevent Prematurity & Stillbirth, Seattle, Washington, United States of America

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  • Craig E. Rubens,

    Affiliations: Center for Childhood Infections and Prematurity Research, Seattle Children's Research Institute, Seattle, Washington, United States of America, Department of Pediatrics, University of Washington, Seattle, Washington, United States of America, Global Alliance to Prevent Prematurity & Stillbirth, Seattle, Washington, United States of America

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  • Lakshmi Rajagopal mail,

    lakshmi.rajagopal@seattlechildrens.org (LR); adamsk@u.washington.edu (KMAW)

    Affiliations: Center for Childhood Infections and Prematurity Research, Seattle Children's Research Institute, Seattle, Washington, United States of America, Department of Pediatrics, University of Washington, Seattle, Washington, United States of America

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  • Kristina M. Adams Waldorf mail

    lakshmi.rajagopal@seattlechildrens.org (LR); adamsk@u.washington.edu (KMAW)

    Affiliations: Department of Obstetrics & Gynecology, University of Washington, Seattle, Washington, United States of America, Center on Human Development and Disability, University of Washington, Seattle, Washington, United States of America

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  • Published: March 06, 2014
  • DOI: 10.1371/journal.ppat.1003920

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