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Research Article

PPARγ Agonists Improve Survival and Neurocognitive Outcomes in Experimental Cerebral Malaria and Induce Neuroprotective Pathways in Human Malaria

  • Lena Serghides mail,

    lena.serghides@utoronto.ca

    Affiliations: Toronto General Research Institute, University Health Network, Toronto, Ontario, Canada, SA Rotman Laboratories, Sandra Rotman Centre for Global Health, University Health Network, Toronto, Ontario, Canada, Women's College Research Institute, Women's College Hospital, Toronto, Ontario, Canada

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  • Chloe R. McDonald equal contributor,

    equal contributor Contributed equally to this work with: Chloe R. McDonald, Ziyue Lu

    Affiliations: SA Rotman Laboratories, Sandra Rotman Centre for Global Health, University Health Network, Toronto, Ontario, Canada, Tropical Disease Unit, Division of Infectious Diseases, Department of Medicine, University of Toronto, Toronto, Ontario, Canada

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  • Ziyue Lu equal contributor,

    equal contributor Contributed equally to this work with: Chloe R. McDonald, Ziyue Lu

    Affiliations: SA Rotman Laboratories, Sandra Rotman Centre for Global Health, University Health Network, Toronto, Ontario, Canada, Tropical Disease Unit, Division of Infectious Diseases, Department of Medicine, University of Toronto, Toronto, Ontario, Canada

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  • Miriam Friedel,

    Affiliation: Mouse Imaging Centre, Hospital for Sick Children, Toronto, Ontario, Canada

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  • Cheryl Cui,

    Affiliation: Tropical Disease Unit, Division of Infectious Diseases, Department of Medicine, University of Toronto, Toronto, Ontario, Canada

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  • Keith T. Ho,

    Affiliation: Department of Physiology, University of Toronto, Toronto, Ontario, Canada

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  • Howard T. J. Mount,

    Affiliations: Department of Physiology, University of Toronto, Toronto, Ontario, Canada, Department of Psychiatry, Department of Medicine, University of Toronto, Toronto, Ontario, Canada

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  • John G. Sled,

    Affiliations: Mouse Imaging Centre, Hospital for Sick Children, Toronto, Ontario, Canada, Department of Medical Biophysics, University of Toronto, Toronto, Ontario, Canada

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  • Kevin C. Kain

    Affiliations: Toronto General Research Institute, University Health Network, Toronto, Ontario, Canada, SA Rotman Laboratories, Sandra Rotman Centre for Global Health, University Health Network, Toronto, Ontario, Canada, Tropical Disease Unit, Division of Infectious Diseases, Department of Medicine, University of Toronto, Toronto, Ontario, Canada

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  • Published: March 06, 2014
  • DOI: 10.1371/journal.ppat.1003980

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