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Research Article

Hepatitis B Virus Infection and Immunopathogenesis in a Humanized Mouse Model: Induction of Human-Specific Liver Fibrosis and M2-Like Macrophages

  • Moses T. Bility mail,

    moses_bility@med.unc.edu (MTB); lsu@med.unc.edu (LS)

    Affiliation: Lineberger Comprehensive Cancer Center, Department of Microbiology and Immunology, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, United States of America

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  • Liang Cheng,

    Affiliation: Lineberger Comprehensive Cancer Center, Department of Microbiology and Immunology, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, United States of America

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  • Zheng Zhang,

    Affiliation: Center of Infectious Disease, Beijing 302 Hospital, Beijing, China

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  • Yan Luan,

    Affiliations: Lineberger Comprehensive Cancer Center, Department of Microbiology and Immunology, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, United States of America, Center for Infection and Immunity, Institute of Biophysics, Chinese Academy of Sciences, Beijing, China, Department of Pathology, University of Chicago, Chicago, Illinois, United States of America

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  • Feng Li,

    Affiliation: Lineberger Comprehensive Cancer Center, Department of Microbiology and Immunology, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, United States of America

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  • Liqun Chi,

    Affiliation: Lineberger Comprehensive Cancer Center, Department of Microbiology and Immunology, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, United States of America

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  • Liguo Zhang,

    Affiliation: Center for Infection and Immunity, Institute of Biophysics, Chinese Academy of Sciences, Beijing, China

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  • Zhengkun Tu,

    Affiliations: Lineberger Comprehensive Cancer Center, Department of Microbiology and Immunology, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, United States of America, Department of Translational Medicine, Department of Surgery, Department of Medicine, the First Hospital, Jilin University, Changchun, Jilin, China

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  • Yanhang Gao,

    Affiliation: Department of Translational Medicine, Department of Surgery, Department of Medicine, the First Hospital, Jilin University, Changchun, Jilin, China

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  • Yangxin Fu,

    Affiliations: Center for Infection and Immunity, Institute of Biophysics, Chinese Academy of Sciences, Beijing, China, Department of Pathology, University of Chicago, Chicago, Illinois, United States of America

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  • Junqi Niu,

    Affiliation: Department of Translational Medicine, Department of Surgery, Department of Medicine, the First Hospital, Jilin University, Changchun, Jilin, China

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  • Fusheng Wang,

    Affiliation: Center of Infectious Disease, Beijing 302 Hospital, Beijing, China

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  • Lishan Su mail

    moses_bility@med.unc.edu (MTB); lsu@med.unc.edu (LS)

    Affiliations: Lineberger Comprehensive Cancer Center, Department of Microbiology and Immunology, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, United States of America, Center for Infection and Immunity, Institute of Biophysics, Chinese Academy of Sciences, Beijing, China, Department of Translational Medicine, Department of Surgery, Department of Medicine, the First Hospital, Jilin University, Changchun, Jilin, China

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  • Published: March 20, 2014
  • DOI: 10.1371/journal.ppat.1004032

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