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Featured Opinion

Malaria Vaccines: Where Next?

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Anthony Holder discusses the current state of malaria vaccine research, and proposes new areas of focus for moving forward, including immunity, merozoites, and assay development.

Image Credit: Tim Brauhn

 

Featured Research

Glypican-1 Mediates Both Prion Protein Lipid Raft Association and Disease Isoform Formation

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Taylor et al. propose that glypican-1 acts as a scaffold facilitating the favorable interaction of the misfolded, infectious form of the prion protein with the normal cellular form within cholesterol-rich lipid rafts. Their results indicate that glypican-1 is intimately involved in the misfolding of the prion protein.

 

Major Depletion of Plasmacytoid Dendritic Cells in HIV-2 Infection, an Attenuated Form of HIV Disease

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Cavaleiro et al. characterize blood plasmacytoid dendritic cells (pDC), important mediators between innate and acquired immunity, in HIV-2 infection. Overall, their data suggest that the presence of virus in circulation, although not critical for the reduction in pDC number, appears to be central for the impairment of their function.

 

A Novel System of Cytoskeletal Elements in the Human Pathogen Helicobacter pylori

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Waidner et al. show that H. pylori has a novel type of system setting up helical cell shape, not previously described for any bacterium. They demonstrate that the helical cell shape depends on coiled coil rich proteins, which form extended filamentous structures in vitro and in vivo, and are differentially required for the maintenance of proper cell morphology.

 

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