Egress is the process by which intracellular pathogens escape their host cell and as such represents a critical process for any intracellular pathogen's success. In this Pearls article, Ana Traven and Thomas Naderer discuss current understanding of egress and its impact on the host.
Understanding the causes of localized HIV shedding is critical to develop novel preventative strategies. In recent studies, Lance Price, Rupert Kaul, and colleagues evaluate the semen microbiome, bacterial load, and cytokine levels in HIV-infected and non HIV-infected men who have sex with men, finding that HIV infection reduces semen microbiome biodiversity and is associated with semen cytokine levels.
Pseudomonas syringae pv. tomato, the causal agent of bacterial speck, is a significant model system for studying molecular plant-pathogen interactions. Gregory Martin and colleagues report new insights into how the AvrPtoB effector can be recognized by the tomato kinase Pto to activate immunity.
Herpes simplex viruses (HSV) provide one of the best-described examples of viral latency and reactivation. Using single cell analysis of transcription in mice dorsal root ganglia, Joel Ma, Francis Carbone, David Tscharke, and colleagues reveal that HSV-1 latency is highly dynamic in the majority of neurons and involves an active host response to frequent viral activity.
Aris Katzourakis, Gkikas Magiorkinis and colleagues have discovered a correlation between larger mammalian body size and fewer cancer-causing ERV's (endogenous retroviruses) in those mammals' genomes, leading the team to conclude that larger mammals have evolved mechanisms to limit ERV activity. Read more about this research in news selections from Science Magazine and The Independent.
Meet Editor-in-Chief Grant McFadden and the PLOS Pathogens team at the International Union of Microbiological Societies Congress in Montréal, Canada July 27- August 1. If you are at the conference, come visit the PLOS booth. Stay tuned @PLOSPathogens on twitter for live updates from PLOS Pathogens and PLOS NTDs editors' talks.
Image credit: www.nfmikro.net